The saga between Ryan Pressly and the Astros is over.

They’re trading the talented reliever to the Cubs, The Post’s Jon Heyman confirmed, after he agreed to waive his no-trade clause.

He’ll get an assignment bonus to cover the tax difference and another full no-trade clause.

Houston will also send money to Chicago to help cover his $14 million salary, according to ESPN.

The Astros asked Pressly to waive his no-trade clause and accept a move to the Cubs on Friday, Heyman previously reported, but he was reluctant to leave Houston, where his family lives year-round.

Two days later, he’s seemingly been convinced.

The trade marks the second major deal between the Astros and Cubs this offseason.

The Cubs notably acquired star outfielder Kyle Tucker last month, sending Isaac Paredes, Hayden Wesneski and Cam Smith to the Astros in exchange.

Pressly, 36, lost his closer role last year when the Astros signed Josh Hader to a five-year, $95 million deal last offseason.

It relegated Pressly to the setup-man role, where he recorded a 3.49 ERA in 59 total outings.

Across six-plus years with the Astros, Pressly recorded a 2.81 ERA, 111 saves and 11.1 strikeouts-per-nine-innings.

He was named to two All-Star teams, in 2019 and 2021, and was integral to the Astros’ World Series title in 2022.

Before Houston, Pressly spent six-plus years with the Twins, for whom he recorded a 3.75 ERA.

He’s expected to return to his closer role with the Cubs, who as a team blew 26 saves last year.

The Cubs also signed added Eli Morgan, Cody Poteet, Matt Festa, Caleb Thielbar and Rob Zastryzny to their bullpen this offseason.

Adbert Alzolay struggled as the Cubs’ closer last year before he got hurt and eventually needed Tommy John surgery, and he signed with the Mets on Friday.

Porter Hodge finished last season as the team’s closer and is still on the roster, but Pressly provides far more experience and a much larger body of work.

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